A rare opportunity to own a distinctive mixed-use property offering exceptional flexibility for commercial, residential, or live/work use. The main level features expansive commercial space with the potential to extend that use into the second floor, or maintain commercial space on the main level with the upper level utilized as a private residence or income-producing rental. (Four Winds Apothecary to vacate by the end of February 2026.) Reported to be the 2nd oldest building in the village of Amana, 4506 220th Trl enjoys a prime location among the area's established retail businesses, adding both historical significance and strong visibility. The main floor offers approximately 3,559 finished sqft, with an additional 2,400 finished sqft on the second level, totaling approximately 5,959 finished sqft. The upper-level living quarters include spacious living & dining rooms, a full kitchen, 3 full bathrooms, 2 1/2 baths, and a dedicated laundry room-ideal for owner occupancy or rental income. This sale includes three separate parcels:104009082, 104009086, 104009088. All square footage and property taxes to be verified by the buyer.